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- Title
Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study.
- Authors
Rapoport, J L; Giedd, J N; Blumenthal, J; Hamburger, S; Jeffries, N; Fernandez, T; Nicolson, R; Bedwell, J; Lenane, M; Zijdenbos, A; Paus, T; Evans, A
- Abstract
Adolescence provides a window to examine regional and disease-specific late abnormal brain development in schizophrenia. Because previous data showed progressive brain ventricular enlargement for a group of adolescents with childhood-onset schizophrenia at 2-year follow-up, with no significant changes for healthy controls, we hypothesized that there would be a progressive decrease in volume in other brain tissue in these patients during adolescence.
- Publication
Archives of general psychiatry, 1999, Vol 56, Issue 7, p649
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.56.7.649