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- Title
Gamma frequency-range abnormalities to auditory stimulation in schizophrenia.
- Authors
Kwon, J S; O'Donnell, B F; Wallenstein, G V; Greene, R W; Hirayasu, Y; Nestor, P G; Hasselmo, M E; Potts, G F; Shenton, M E; McCarley, R W
- Abstract
Basic science studies at the neuronal systems level have indicated that gamma-range (30-50 Hz) neural synchronization may be a key mechanism of information processing in neural networks, reflecting integration of various features of an object. Furthermore, gamma-range synchronization is thought to depend on the glutamatergically mediated interplay between excitatory projection neurons and inhibitory neurons utilizing gamma-aminobutyric acid (GABA), which postmortem studies suggest may be abnormal in schizophrenia. We therefore tested whether auditory neural networks in patients with schizophrenia could support gamma-range synchronization.
- Publication
Archives of general psychiatry, 1999, Vol 56, Issue 11, p1001
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.56.11.1001