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- Title
Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia.
- Authors
Heresco-Levy, U; Javitt, D C; Ermilov, M; Mordel, C; Silipo, G; Lichtenstein, M
- Abstract
Disturbances of N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission may play an important role in the pathophysiology of negative symptoms of schizophrenia. Glycine, a small nonessential amino acid, functions as an obligatory coagonist at NMDA receptors through its action at a strychnine-insensitive binding site on the NMDA receptor complex. Glycine-induced augmentation of NMDA receptor-mediated neurotransmission may thus offer a potentially safe and feasible approach for ameliorating persistent negative symptoms of schizophrenia.
- Publication
Archives of general psychiatry, 1999, Vol 56, Issue 1, p29
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.56.1.29