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- Title
Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations.
- Authors
Lappalainen, J; Long, J C; Eggert, M; Ozaki, N; Robin, R W; Brown, G L; Naukkarinen, H; Virkkunen, M; Linnoila, M; Goldman, D
- Abstract
In mice, quantitative trait locus studies and behavioral evaluation of animals deleted for 5-HT1B have implicated this serotonin autoreceptor in alcohol consumption and aggressive behavior. We therefore investigated whether the 5-HT1B gene (HTR1B) is linked to alcoholism with aggressive and impulsive behavior in the human, as represented by 2 psychiatric diagnoses: antisocial personality disorder and intermittent explosive disorder comorbid with alcoholism.
- Publication
Archives of general psychiatry, 1998, Vol 55, Issue 11, p989
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.55.11.989