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- Title
Role of the serotonin transporter promoter polymorphism in anxiety-related traits.
- Authors
Mazzanti, C M; Lappalainen, J; Long, J C; Bengel, D; Naukkarinen, H; Eggert, M; Virkkunen, M; Linnoila, M; Goldman, D
- Abstract
The heritability of interindividual variation in anxiety and other aspects of personality establishes that variants of genes influence these traits. A functional polymorphism in the promoter of the human serotonin transporter gene (SLC6A4*C) was identified and found to be linked to an anxiety-related personality trait, Neuroticism. The polymorphism affects gene transcription and, ultimately, gene function. We have attempted to confirm the role of SLC6A4*C in anxiety-related personality traits by sibpair analysis and association studies.
- Publication
Archives of general psychiatry, 1998, Vol 55, Issue 10, p936
- ISSN
0003-990X
- Publication type
Journal Article
- DOI
10.1001/archpsyc.55.10.936