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- Title
Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
- Authors
Wagner, Steven L; Tanzi, Rudolph E; Mobley, William C; Galasko, Douglas
- Abstract
Although significant progress has occurred in the past 20 years regarding our understanding of Alzheimer disease pathogenesis, we have yet to identify disease-modifying therapeutics capable of substantially altering the clinical course of this prevalent neurodegenerative disease. In this short review, we discuss 2 approaches that are currently being tested clinically (γ-secretase inhibition and γ-secretase modulation) and emphasize the significant differences between these 2 therapeutic approaches. We also discuss certain genetic- and biomarker-based translational and clinical trial paradigms that may assist in developing a useful therapeutic agent.
- Publication
Archives of neurology, 2012, Vol 69, Issue 10, p1255
- ISSN
1538-3687
- Publication type
Journal Article
- DOI
10.1001/archneurol.2012.540