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- Title
Quantification and functional characterization of antibodies to native aquaporin 4 in neuromyelitis optica.
- Authors
Kalluri, Sudhakar Reddy; Illes, Zsolt; Srivastava, Rajneesh; Cree, Bruce; Menge, Til; Bennett, Jeffrey L; Berthele, Achim; Hemmer, Bernhard
- Abstract
Antibodies targeting membrane proteins play an important role in various autoimmune diseases of the nervous system. So far, assays allowing proper analysis of such autoantibodies are largely missing. A serum autoantibody to aquaporin 4 (AQP4) is associated with neuromyelitis optica (NMO). Although several assays are able to detect this autoantibody, they do not allow determination of the biological activity of anti-AQP4 antibodies.
- Publication
Archives of neurology, 2010, Vol 67, Issue 10, p1201
- ISSN
1538-3687
- Publication type
Journal Article
- DOI
10.1001/archneurol.2010.269