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- Title
Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness.
- Authors
Geser, Felix; Robinson, John L; Malunda, Joseph A; Xie, Sharon X; Clark, Chris M; Kwong, Linda K; Moberg, Paul J; Moore, Erika M; Van Deerlin, Vivianna M; Lee, Virginia M-Y; Arnold, Steven E; Trojanowski, John Q
- Abstract
Major psychiatric diseases such as schizophrenia and mood disorders have not been linked to a specific pathology, but their clinical features overlap with some aspects of the behavioral variant of frontotemporal lobar degeneration. Although the significance of pathological 43-kDa (transactivation response) DNA-binding protein (TDP-43) for frontotemporal lobar degeneration was appreciated only recently, the prevalence of TDP-43 pathology in patients with severe mental illness vs controls has not been systematically addressed.
- Publication
Archives of neurology, 2010, Vol 67, Issue 10, p1238
- ISSN
1538-3687
- Publication type
Journal Article
- DOI
10.1001/archneurol.2010.254