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- Title
Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease.
- Authors
Alcalay, Roy N; Mejia-Santana, Helen; Tang, Ming Xin; Rosado, Llency; Verbitsky, Miguel; Kisselev, Sergey; Ross, Barbara M; Louis, Elan D; Comella, Cynthia L; Colcher, Amy; Jennings, Danna; Nance, Martha A; Bressman, Susan; Scott, William K; Tanner, Caroline; Mickel, Susan F; Andrews, Howard F; Waters, Cheryl H; Fahn, Stanley; Cote, Lucien J; Frucht, Steven J; Ford, Blair; Rezak, Michael; Novak, Kevin; Friedman, Joseph H; Pfeiffer, Ronald; Marsh, Laura; Hiner, Bradley; Siderowf, Andrew; Caccappolo, Elise; Ottman, Ruth; Clark, Lorraine N; Marder, Karen S
- Abstract
To determine the motor phenotype of LRRK2 G2019S mutation carriers. LRRK2 mutation carriers were previously reported to manifest the tremor dominant motor phenotype, which has been associated with slower motor progression and less cognitive impairment compared with the postural instability and gait difficulty (PIGD) phenotype.
- Publication
Archives of neurology, 2009, Vol 66, Issue 12, p1517
- ISSN
1538-3687
- Publication type
Journal Article
- DOI
10.1001/archneurol.2009.267