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- Title
Friedreich ataxia.
- Authors
Pandolfo, Massimo
- Abstract
Friedreich ataxia is an autosomal recessive degenerative disease that primarily affects the nervous system and the heart. It is named after its original description as a "degenerative atrophy of the posterior columns of the spinal cord" by Nicholaus Friedreich, who was a professor of medicine in Heidelberg in the second half of the 19th century. The full extent of the Friedreich ataxia phenotype and its genetic epidemiology could only be appreciated after a direct genetic test became available in 1996. At the same time, the complex pathogenesis of Friedreich ataxia started to be unraveled. Herein, I review our current knowledge of the disease and how it is contributing to the development of therapeutic approaches.
- Publication
Archives of neurology, 2008, Vol 65, Issue 10, p1296
- ISSN
1538-3687
- Publication type
Journal Article
- DOI
10.1001/archneur.65.10.1296