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- Title
Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging.
- Authors
Sabbagh, Marwan N; Shah, Flora; Reid, Richard T; Sue, Lucia; Connor, Donald J; Peterson, Lars Kristofer N; Beach, Thomas G
- Abstract
Neurochemical and pathologic studies show that mild cognitive impairment (MCI) is frequently a transitional state between normal aging and Alzheimer disease (AD). Neuropathologic sample sizes have been limited because relatively few individuals with MCI die before dementia develops. Decreased neocortical nicotinic receptor binding is characteristic of AD but has not been investigated in subjects with MCI.
- Publication
Archives of neurology, 2006, Vol 63, Issue 12, p1771
- ISSN
0003-9942
- Publication type
Journal Article
- DOI
10.1001/archneur.63.12.1771