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- Title
Late-onset Friedreich ataxia: phenotypic analysis, magnetic resonance imaging findings, and review of the literature.
- Authors
Bhidayasiri, Roongroj; Perlman, Susan L; Pulst, Stefan-M; Geschwind, Daniel H
- Abstract
Friedreich ataxia (FA), the most common hereditary ataxia, is caused by pathological expansion of GAA repeats in the first intron of the X25 gene on chromosome 9. Since the discovery of the gene, atypical features are increasingly recognized in individuals with FA, and up to 25% of patients with recessive or sporadic ataxia do not fulfill the Harding or Quebec Cooperative Study on Friedreich's Ataxia criteria for FA. Late-onset FA (LOFA) is defined as onset after age 25 years.
- Publication
Archives of neurology, 2005, Vol 62, Issue 12, p1865
- ISSN
0003-9942
- Publication type
Journal Article
- DOI
10.1001/archneur.62.12.1865