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- Title
Gene vaccination to bias the immune response to amyloid-beta peptide as therapy for Alzheimer disease.
- Authors
Qu, Baoxi; Rosenberg, Roger N; Li, Liping; Boyer, Philip J; Johnston, Stephen A
- Abstract
The amyloid-beta (Abeta) peptide has a central role in the neurodegeneration of Alzheimer disease (AD). Immunization of AD transgenic mice with Abeta(1-42) (Abeta(42)) peptide reduces both the spatial memory impairments and AD-like neuropathologic changes in these mice. Therapeutic immunization with Abeta in patients with AD was shown to be effective in reducing Abeta deposition, but studies were discontinued owing to the development of an autoimmune, cell-mediated meningoencephalitis. We hypothesized that gene vaccination could be used to generate an immune response to Abeta(42) that produced antibody response but avoided an adverse cell-mediated immune effect.
- Publication
Archives of neurology, 2004, Vol 61, Issue 12, p1859
- ISSN
0003-9942
- Publication type
Journal Article
- DOI
10.1001/archneur.61.12.1859