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- Title
Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment.
- Authors
Guillozet, Angela L; Weintraub, Sandra; Mash, Deborah C; Mesulam, M Marsel
- Abstract
Large numbers of neurofibrillary tangles (NFTs) and amyloid plaques are diagnostic markers for Alzheimer disease (AD), but lesser numbers of these lesions are also seen in nondemented elderly individuals. Much of the existing literature suggests that the NFTs of AD have a closer correlation with cognitive function than do amyloid plaques. Whether a similar relationship exists in normal aging and mild cognitive impairment (MCI), a condition that frequently reflects a preclinical stage of AD, remains unknown.
- Publication
Archives of neurology, 2003, Vol 60, Issue 5, p729
- ISSN
0003-9942
- Publication type
Journal Article
- DOI
10.1001/archneur.60.5.729