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- Title
Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease.
- Authors
Hauser, R A; Freeman, T B; Snow, B J; Nauert, M; Gauger, L; Kordower, J H; Olanow, C W
- Abstract
Parkinson disease (PD) is associated with a progressive loss of nigrostriatal dopamine neurons. Medication therapy provides adequate control of symptoms for several years, but long-term treatment is complicated by progressive disability and the development of motor fluctuations and dyskinesias. In animal models of PD, fetal nigral transplants have been shown to survive grafting into the striatum, provide extensive striatal reinnervation, and improve motor function. In patients with PD, cell survival and clinical benefit have been observed following fetal nigral grafting, but results have been inconsistent.
- Publication
Archives of neurology, 1999, Vol 56, Issue 2, p179
- ISSN
0003-9942
- Publication type
Journal Article
- DOI
10.1001/archneur.56.2.179