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- Title
Effect of 1-year oral administration of dehydroepiandrosterone to 60- to 80-year-old individuals on muscle function and cross-sectional area: a double-blind placebo-controlled trial.
- Authors
Percheron, Gaëlle; Hogrel, Jean-Yves; Denot-Ledunois, Sonjà; Fayet, Guillemette; Forette, Françoise; Baulieu, Etienne-Emile; Fardeau, Michel; Marini, Jean-François; Double-blind placebo-controlled trial
- Abstract
The age-related decline of dehydroepiandrosterone and its sulfate ester levels is thought to be related to the development of age-associated usual modifications, such as neuromuscular function impairments. It is often claimed that individuals can enhance their muscular capacity by boosting dehydroepiandrosterone levels through oral supplementation. However, to our knowledge, there have been no controlled studies on a significant number of individuals demonstrating positive effects on the neuromuscular system. This study determines if 1-year administration of a replacement dose of dehydroepiandrosterone, 50 mg/d, orally administered, could have a beneficial influence on several determinants of the muscular function altered during aging.
- Publication
Archives of internal medicine, 2003, Vol 163, Issue 6, p720
- ISSN
0003-9926
- Publication type
Journal Article
- DOI
10.1001/archinte.163.6.720