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- Title
Magnetic resonance imaging in late-life depression: multimodal examination of network disruption.
- Authors
Sexton, Claire E; Allan, Charlotte L; Le Masurier, Marisa; McDermott, Lisa M; Kalu, Ukwuori G; Herrmann, Lucie L; Mäurer, Matthias; Bradley, Kevin M; Mackay, Clare E; Ebmeier, Klaus P
- Abstract
Disruption of frontal-subcortical and limbic networks is hypothesized to have a key role in late-life depression (LLD) and can be examined using magnetic resonance imaging (MRI) techniques. Gray matter can be examined using T1-weighted MRI, white matter using T2-weighted MRI and diffusion tensor imaging, and functional connectivity in resting-state networks using functional MRI. Although independent MRI studies have supported gray and white matter abnormalities in frontosubcortical and limbic networks and increased functional connectivity in the default-mode network in depression, no study has concurrently examined gray matter, white matter, and functional connectivity.
- Publication
Archives of general psychiatry, 2012, Vol 69, Issue 7, p680
- ISSN
1538-3636
- Publication type
Journal Article
- DOI
10.1001/archgenpsychiatry.2011.1862