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- Title
Enhanced carbonyl stress in a subpopulation of schizophrenia.
- Authors
Arai, Makoto; Yuzawa, Hiroko; Nohara, Izumi; Ohnishi, Tetsuo; Obata, Nanako; Iwayama, Yoshimi; Haga, Seiichi; Toyota, Tomoko; Ujike, Hiroshi; Arai, Mayumi; Ichikawa, Tomoe; Nishida, Atsushi; Tanaka, Yoko; Furukawa, Aizo; Aikawa, Yuuzou; Kuroda, Osamu; Niizato, Kazuhiro; Izawa, Ryosuke; Nakamura, Kazuhiko; Mori, Norio; Matsuzawa, Daisuke; Hashimoto, Kenji; Iyo, Masaomi; Sora, Ichiro; Matsushita, Masaaki; Okazaki, Yuji; Yoshikawa, Takeo; Miyata, Toshio; Itokawa, Masanari
- Abstract
Various factors are involved in the pathogenesis of schizophrenia. Accumulation of advanced glycation end products, including pentosidine, results from carbonyl stress, a state featuring an increase in reactive carbonyl compounds (RCOs) and their attendant protein modifications. Vitamin B(6) is known to detoxify RCOs, including advanced glycation end products. Glyoxalase I (GLO1) is one of the enzymes required for the cellular detoxification of RCOs.
- Publication
Archives of general psychiatry, 2010, Vol 67, Issue 6, p589
- ISSN
1538-3636
- Publication type
Journal Article
- DOI
10.1001/archgenpsychiatry.2010.62