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- Title
Elevated brain monoamine oxidase A binding in the early postpartum period.
- Authors
Sacher, Julia; Wilson, Alan A; Houle, Sylvain; Rusjan, Pablo; Hassan, Sabrina; Bloomfield, Peter M; Stewart, Donna E; Meyer, Jeffrey H
- Abstract
The early postpartum period is a time of high risk for a major depressive episode (or postpartum depression), with a prevalence of 13%. During this time, there is a heightened vulnerability for low mood because postpartum blues is common. Severe postpartum blues can herald the onset of postpartum depression. The neurobiological mechanisms to explain postpartum blues and the high risk for the onset of postpartum depression in the first few weeks after delivery are unclear. Estrogen levels drop 100- to 1000-fold during the first 3 to 4 days postpartum, and changes in estrogen levels have an inverse relationship with monoamine oxidase A (MAO-A) density. However, MAO-A levels have never been measured in the early postpartum period.
- Publication
Archives of general psychiatry, 2010, Vol 67, Issue 5, p468
- ISSN
1538-3636
- Publication type
Journal Article
- DOI
10.1001/archgenpsychiatry.2010.32