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- Title
The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.
- Authors
Schjeide, Brit-Maren M; Schnack, Cathrin; Lambert, Jean-Charles; Lill, Christina M; Kirchheiner, Julia; Tumani, Hayrettin; Otto, Markus; Tanzi, Rudolph E; Lehrach, Hans; Amouyel, Philippe; von Arnim, Christine A F; Bertram, Lars
- Abstract
Two recent and simultaneously published genome-wide association studies independently implicated clusterin (CLU), complement receptor 1 (CR1), and phosphatidylinositol binding clathrin assembly protein (PICALM) as putative novel Alzheimer disease (AD) risk loci. Despite their strong statistical support, all 3 signals emerged from heterogeneous case-control populations and lack replication in different settings.
- Publication
Archives of general psychiatry, 2011, Vol 68, Issue 2, p207
- ISSN
1538-3636
- Publication type
Journal Article
- DOI
10.1001/archgenpsychiatry.2010.196