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- Title
Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression.
- Authors
Raison, Charles L; Lowry, Christopher A; Rook, Graham A W
- Abstract
Inflammation is increasingly recognized as contributing to the pathogenesis of major depressive disorder (MDD), even in individuals who are otherwise medically healthy. Most studies in search of sources for this increased inflammation have focused on factors such as psychosocial stress and obesity that are known to activate inflammatory processes and increase the risk for depression. However, MDD may be so prevalent in the modern world not just because proinflammatory factors are widespread, but also because we have lost contact with previously available sources of anti-inflammatory, immunoregulatory signaling.
- Publication
Archives of general psychiatry, 2010, Vol 67, Issue 12, p1211
- ISSN
1538-3636
- Publication type
Journal Article
- DOI
10.1001/archgenpsychiatry.2010.161