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- Title
Influence of cognitive status, age, and APOE-4 genetic risk on brain FDDNP positron-emission tomography imaging in persons without dementia.
- Authors
Small, Gary W; Siddarth, Prabha; Burggren, Alison C; Kepe, Vladimir; Ercoli, Linda M; Miller, Karen J; Lavretsky, Helen; Thompson, Paul M; Cole, Greg M; Huang, S C; Phelps, Michael E; Bookheimer, Susan Y; Barrio, Jorge R
- Abstract
Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer disease that accumulate in the brains of people without dementia years before they develop dementia. Positron emission tomography (PET) scans after intravenous injections of 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile (FDDNP), which binds to plaques and tangles in vitro, demonstrate increased cerebral binding in patients with Alzheimer disease compared with cognitively intact controls. Here we investigated whether known risk factors for Alzheimer disease and dementia are associated with FDDNP-PET binding.
- Publication
Archives of general psychiatry, 2009, Vol 66, Issue 1, p81
- ISSN
1538-3636
- Publication type
Journal Article
- DOI
10.1001/archgenpsychiatry.2008.516