Kinetics of the Enolisation Reaction of m-Nitro Acetophenone Catalyzed by Amino Acids.

Malhotra, Swati; Jaspal, Dipika

m-Nitroacetophenone has been chosen for the study of kinetics of enolisation. Enolisation reactions have been carried out using four different amino acids viz. β-alanin, DL-alanin, L-alanin and Glycine. The rate of the reaction has been studied by iodination. Kinetics of the reaction has been monitored under several conditions by variation of ketone concentration, dielectric constant of the medium, temperature, effect of catalysts, etc. for the enolisation process. The rate of enolisation has been found to increase with the increase in ketone concentration, percentage composition of the solvent mixture and also with the increase in the dipole moments of the amino acids. Pseudo first order rate kinetics has been found to be operational and the rate constants have been found to increase with the increase in the amino acid molarities. Linear plots obtained for log of rate constants versus reciprocal of temperature have been in good agreement with the Arrhenius equation. The values of thermodynamic parameters, like entropy (ΔS≠), enthalpy (ΔH≠), energy of activation (ΔEa), and Gibbs free energy (ΔG≠), have been calculated which were 2.6186 e.u., 20.85 e.u., 23.46 kcal.mole-1 and 20.0 kcal.mole-1, respectively.

ACETOPHENONE; ENOLIZATION; AMINO acids; IODINATION; GLYCINE

Bulletin of Chemical Reaction Engineering & Catalysis, 2014, Vol 9, Issue 1, p16

1978-2993

Academic Journal

10.9767/bcrec.9.1.5258.16-22