AIDS was first diagnosed in the year of 1981 in the USA, but it became a current issue all over the world. In Turkey, it was 1985 when the first case was seen. According to the predictions of UNICEF in their common study with United Nations, HIV/AIDS epidemic has been affecting approximately 42 million people today (Green, 2007; UNIADS/WHO, 2012). Since its birth to today, it has caused 20 million people to die. The perception of all society to such an epidemic like AIDS is clearly important; however, the perceptions of student teachers who will raise our future generations are more important. Furthermore, an emotional semantic difference scale was developed in the study, and it is expected to contribute to the results of this study significantly. The purpose of the study is to examine the positive and negative attitudes of teacher candidates about the AIDS according to emotional values in semantic differentiation scale. The survey model that applied at quantitative studies is used in the research. This study was conducted with the participation of 288 teacher candidates. A unipolar questionnaire consisted of 26 two opposite attributes questions has been created to determine the views of teacher candidates regarding AIDS. For the general of the semantic differential attitudes scale the Cronbach Alpha Reliability Coefficients have been found as 0.93. Descriptive statistical methods and independent group t-test were used for analyzing the data with the SPSS-15 and the NVivo-9.3 were used for preparing the Model. At the end of the research, it was determined that teacher candidates' semantic attitudes towards AIDS were at a negative level in terms of mean scores of all adjectives considered. However based on each and every adjective, they mostly perceive AIDS as the contagious, horrible, disgusting, filthy, and death. As a result of the evaluation in terms of gender and social and science sections, it was found out that average of teacher candidates' semantic attitudes towards AIDS did not show a statistically significant difference. Finally, further studies can also be conducted to determine the needs necessary to improve teacher candidates' positive attitudes of AIDS and evaluate the findings considering further teacher education.