In August 2006, Law No. 11,340, known as Lei Maria da Penha, was signed, creating mechanisms to curb domestic and family violence against women. Its adoption was a milestone, because it deals fully with the problem of this type of violence, with the intention of reducing the indicators of crime specific to this gender, but the numbers continue to increase. Accordingly, the objective of this research was to evaluate the influence of the Maria da Penha Law on the mortality of women from external causes in Brazil. To this end, a regression model with panel data analysis was developed with a 21-year (2000-2020) time cut-off. Murders against women by hanging, strangulation or suffocation, sharp and blunt objects have been reduced. However, in the case of crimes carried out with the use of the firearm and not identified, there was no statistical evidence of their decreases. Therefore, the results of the research suggest that the Maria da Penha Law brought about a reduction in the mortality of women from different types of aggression.