Why you should read this article: • To enhance your awareness of the skills required for educating patients about anticancer therapy • To find advice and resources for delivering effective pre-treatment patient education sessions • To contribute towards revalidation as part of your 35 hours of CPD (UK readers) • To contribute towards your professional development and local registration renewal requirements (non-UK readers). Systemic anticancer therapy (SACT) incorporates all types of therapies used to treat cancer, including cytotoxic therapy (also called chemotherapy), immunotherapy, hormonal therapies and targeted therapies. Nurse-led pre-SACT patient education sessions aim to inform patients about their treatment, including its potential side effects and what they should do if they experience symptoms, to enhance patient safety and to reinforce informed consent. This article discusses the importance of pre-SACT patient education sessions in the context of cytotoxic therapy and details six areas for nurses to consider when planning on delivering such sessions.