戒烟后 COPD 患者肺气肿 CT 定量指标变化的纵向研究.

李 艳; 代永亮; 沈 聪; 银 楠; 王 君; 郭佑民; 马光明; 于 楠

Objective To make a longitudinal investigation on the changes in quantitative indicators of emphysema in patients with chronic obstructive pulmonary disease (COPD) after smoking cessation based on CT quantitative technique. Methods A retrospective collection of 130 patients with COPD in the “Digital Lung 1” Database Center (2 times of chest CT scanning at an interval of 2 years), according to the current smoking status, were divided into non-smoking group, smoking group, smoking cessation group, and smoking cessation group according to the smoking cessation time limit, were divided into short-term smoking cessation group and long-term smoking cessation group. Two lung volumes, PD15, two lung %LAA-950, and each lung lobe %LAA-950 were analyzed using the “digital lung” emphysema quantitative software. Differences in quantitative indicators of emphysema before and after smoking cessation were compared between the groups. Results In the non-smoking group, the right lower lobe %LAA-950 at the second time was higher than that at the first time (P<0.05). In the smoking group, the two lungs and the upper lobe of the lungs %LAA-950 in the second time were higher than those in the first time (P<0.05). In the smoking cessation group, the right lung mid-lobe %LAA-950 at the second time was higher than that at the first time (P<0.05). In the short-term group of smoking cessation, the two lungs and the right mid-lobe %LAA-950 at the second time were higher than those at the first time (P<0.05). The quantitative indicators of emphysema in the long-term smoking cessation group were not significantly different (P >0.05). Conclusion CT quantitative analysis can visually show the changes in quantitative indicators of emphysema in COPD patients after smoking cessation, and smoking cessation can effectively delay the progression of emphysema.

Journal of Xi'an Jiaotong University (Medical Sciences), 2018, Vol 39, Issue 6, p893

1671-8259

Academic Journal

10.7652/jdyxb201806024