Objective To explore the prospect of new pancreatic duct jejunostomy applied in clinic. Methods We randomly 53 patients to undergo pancreaticoduodenectomy because of tumors around the ampulla divided into observation group and control group. The observation group adopted the new method of embedding pancreatic duct jejunostomy. The control group was treated with the traditional jejunal anastomosis method. Differences were observed between the two groups in terms of operation time, postoperative infection, bleeding, incidence of pancreatic fistula, average hospitalization duration and average hospitalization expenses. Results The observation group differed significantly from the control group in the average operation time, the average of hospitalization duration, incidence of postoperative infection, hemorrhage, and pancreatic fistula (P 0.05). Conclusion The new method of embedding pancreatic duct jejunum anastomosis is safe and reliable, and has the advantages of being simple to operate and easy to master. It is a suitable technique worthy of clinical promotion.