中医药对血管新生促进或抑制作用的研究进展.

何建成; 王 利

Application of Chinese medicines in promoting or inhibiting angiogenesis in ischemic cardiovascular and cerebrovascular diseases and tumors is always a hot topic of research. In this paper, we analyze the relevant literature at home and abroad in recent 5 years (2012-2017) and find the herb compounds that develop angiogenesis mainly promote circulation of Qi and blood, such as Xuefu Zhuyu Decoction, Danggui Buxue Decoction, Buyang Huanwu Decoction, Taohong Siwu Decoction, and Qishen Yiqi Decoction; single herbs such as Chuanxiong, Salvia, Astragalus, Ginseng, Panax, safflower, and angelica; Chinese medicines in pair such as Astragalus and Angelica, Chuanxiong and Astragalus, Angelica and red peony. The acting mechanism is closely related to VEGFA and VEGFB and their receptors Flt-1 (VEGFR1), KDR/Flk-1 (VEGFR2), Ang-1 and its receptor Tie-2. Antiangiogenesis medicines are mostly heat and dampness detoxification Sanjie compounds (such as turtle pills, compound bitter ginseng injections, West Huang Wan, Liushen pills, and detoxification and Xiao Zheng drink); single herbs such as turmeric, Scutellaria barbata, Scutellaria, Tripterygium, toad, and scorpion venom. The mechanism is inhibiting the activity of MMPs, such as reducing the expressions of MMP-2 and TIMP-1 or inhibiting the expressions of angiogenic factors such as VEGF and bFGF. By summarizing the role of Chinese medicines in promoting or inhibiting angiogenesis, we hope to provide more ideas for future related research.

Journal of Xi'an Jiaotong University (Medical Sciences), 2018, Vol 39, Issue 6, p775

1671-8259

Academic Journal

10.7652/jdyxb201806001