Works matching AU Umeda, Tomohiro

Results: 27

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.

Published in:

2016

By:

Tomohiro Umeda;
Ono, Kenjiro;
Ayumi Sakai;
Minato Yamashita;
Mineyuki Mizuguchi;
Klein, William L.;
Masahito Yamada;
Hiroshi Mori;
Takami Tomiyama;
Umeda, Tomohiro;
Sakai, Ayumi;
Yamashita, Minato;
Mizuguchi, Mineyuki;
Yamada, Masahito;
Mori, Hiroshi;
Tomiyama, Takami

Publication type:

journal article

Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice.

Published in:

Annals of Clinical & Translational Neurology, 2015, v. 2, n. 3, p. 241, doi. 10.1002/acn3.171

By:

Umeda, Tomohiro;
Eguchi, Hiroshi;
Kunori, Yuichi;
Matsumoto, Yoichi;
Taniguchi, Taizo;
Mori, Hiroshi;
Tomiyama, Takami

Publication type:

Article

New Value of Acorus tatarinowii / gramineus Leaves as a Dietary Source for Dementia Prevention.

Published in:

Nutrients, 2024, v. 16, n. 11, p. 1589, doi. 10.3390/nu16111589

By:

Umeda, Tomohiro;
Sakai, Ayumi;
Shigemori, Keiko;
Nakata, Kunio;
Nakajima, Ryota;
Yamana, Kei;
Tomiyama, Takami

Publication type:

Article

The E693Δ (Osaka) mutation in amyloid precursor protein potentiates cholesterol-mediated intracellular amyloid β toxicity via its impaired cholesterol efflux.

Published in:

Journal of Neuroscience Research, 2013, v. 91, n. 12, p. 1541, doi. 10.1002/jnr.23278

By:

Nomura, Sachiko;
Umeda, Tomohiro;
Tomiyama, Takami;
Mori, Hiroshi

Publication type:

Article

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo.

Published in:

Journal of Neuroscience Research, 2011, v. 89, n. 7, p. 1031, doi. 10.1002/jnr.22640

By:

Umeda, Tomohiro;
Tomiyama, Takami;
Sakama, Naomi;
Tanaka, Saya;
Lambert, Mary P.;
Klein, William L.;
Mori, Hiroshi

Publication type:

Article

Effects of blood on bone cement made of calcium phosphate: Problems and advantages.

Published in:

Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 2010, v. 92B, n. 1, p. 95, doi. 10.1002/jbm.b.31493

By:

Musha, Yoshiro;
Umeda, Tomohiro;
Yoshizawa, Sayuri;
Shigemitsu, Toshio;
Mizutani, Kazuhiro;
Itatani, Kiyoshi

Publication type:

Article

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.

Published in:

Acta Neuropathologica, 2014, v. 127, n. 5, p. 685, doi. 10.1007/s00401-014-1259-1

By:

Umeda, Tomohiro;
Maekawa, Satomi;
Kimura, Tetsuya;
Takashima, Akihiko;
Tomiyama, Takami;
Mori, Hiroshi

Publication type:

Article

Hawaiian native herb Mamaki prevents dementia by ameliorating neuropathology and repairing neurons in four different mouse models of neurodegenerative diseases.

Published in:

GeroScience, 2024, v. 46, n. 2, p. 1971, doi. 10.1007/s11357-023-00950-y

By:

Umeda, Tomohiro;
Shigemori, Keiko;
Uekado, Rumi;
Matsuda, Kazunori;
Tomiyama, Takami

Publication type:

Article

Oligomer-Targeting Prevention of Neurodegenerative Dementia by Intranasal Rifampicin and Resveratrol Combination – A Preclinical Study in Model Mice.

Published in:

Frontiers in Neuroscience, 2021, v. 15, p. 1, doi. 10.3389/fnins.2021.763476

By:

Umeda, Tomohiro;
Sakai, Ayumi;
Shigemori, Keiko;
Yokota, Ayumi;
Kumagai, Toru;
Tomiyama, Takami

Publication type:

Article

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0461-5

By:

Tomohiro Umeda;
Tetsuya Kimura;
Kayo Yoshida;
Keizo Takao;
Yuki Fujita;
Shogo Matsuyama;
Ayumi Sakai;
Minato Yamashita;
Yuki Yamashita;
Kiyouhisa Ohnishi;
Mamiko Suzuki;
Hiroshi Takuma;
Tsuyoshi Miyakawa;
Akihiko Takashima;
Takashi Morita;
Hiroshi Mori;
Takami Tomiyama

Publication type:

Article

Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons.

Published in:

Acta Neuropathologica Communications, 2015, v. 3, n. 1, p. 1, doi. 10.1186/s40478-015-0230-2

By:

Tomohiro Umeda;
Ramser, Elisa M.;
Minato Yamashita;
Koichi Nakajima;
Hiroshi Mori;
Silverman, Michael A.;
Takami Tomiyama

Publication type:

Article

Simply crushed zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice.

Published in:

eLife, 2025, p. 1, doi. 10.7554/eLife.100737

By:

Tomohiro Umeda;
Ayumi Sakai;
Rumi Uekado;
Keiko Shigemori;
Ryota Nakajima;
Kei Yamana;
Takami Tomiyama

Publication type:

Article

Intraneuronal amyloid-beta oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

Published in:

2011

By:

Umeda, Tomohiro;
Tomiyama, Takami;
Sakama, Naomi;
Tanaka, Saya;
Lambert, Mary;
Klein, William;
Mori, Hiroshi

Publication type:

Abstract

Regulation of cholesterol efflux by amyloid β secretion

Published in:

2010

By:

Umeda, Tomohiro;
Mori, Hiroshi;
Zheng, Hui;
Tomiyama, Takami

Publication type:

Abstract

Hypercholesterolemia accelerates memory impairment in a transgenic mouse model of Abeta oligomers

Published in:

2010

By:

Kitajima, Erika;
Umeda, Tomohiro;
Idomoto, Toshiki;
Lambert, Mary P.;
Klein, William L.;
Tomiyama, Takami;
Mori, Hiroshi

Publication type:

Abstract

Intraneuronal accumulation of Aβ oligomers causes abnormal tau phosphorylation, glial activation and neuronal loss in transgenic mice with APP E693Δ mutation

Published in:

2010

By:

Tomiyama, Takami;
Umeda, Tomohiro;
Sakama, Naomi;
Lambert, Mary P.;
Klein, William L.;
Mori, Hiroshi

Publication type:

Abstract

A transgenic mouse model of amyloid β oligomers: Pathological effects of the E693Δ mutation in amyloid precursor protein in vivo

Published in:

2009

By:

Tomiyama, Takami;
Matsuyama, Shogo;
Iso, Hiroyuki;
Takuma, Hiroshi;
Umeda, Tomohiro;
Ohnishi, Kiyouhisa;
Teraoka, Rie;
Ishibashi, Kenichi;
Nishitsuji, Kazuchika;
Ito, Kazuhiro;
Borchelt, David R.;
Lambert, Mary P.;
Klein, William L.;
Mori, Hiroshi

Publication type:

Abstract

Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice.

Published in:

Biomedicines, 2022, v. 10, n. 2, p. 297, doi. 10.3390/biomedicines10020297

By:

Umeda, Tomohiro;
Uekado, Rumi;
Shigemori, Keiko;
Eguchi, Hiroshi;
Tomiyama, Takami

Publication type:

Article

Visualizing and Evaluating Finger Movement Using Combined Acceleration and Contact-Force Sensors: A Proof-of-Concept Study.

Published in:

Sensors (14248220), 2021, v. 21, n. 5, p. 1918, doi. 10.3390/s21051918

By:

Oigawa, Hitomi;
Musha, Yoshiro;
Ishimine, Youhei;
Kinjo, Sumito;
Takesue, Yuya;
Negoro, Hideyuki;
Umeda, Tomohiro;
Najafi, Bijan

Publication type:

Article

C9orf72 Hexanucleotide Repeat Expansion-Related Neuropathology Is Attenuated by Nasal Rifampicin in Mice.

Published in:

Biomedicines, 2022, v. 10, n. 5, p. 1080, doi. 10.3390/biomedicines10051080

By:

Hatanaka, Yukari;
Umeda, Tomohiro;
Shigemori, Keiko;
Takeuchi, Toshihide;
Nagai, Yoshitaka;
Tomiyama, Takami

Publication type:

Article

How Live Performance Moves the Human Heart.

Published in:

PLoS ONE, 2016, v. 11, n. 4, p. 1, doi. 10.1371/journal.pone.0154322

By:

Shoda, Haruka;
Adachi, Mayumi;
Umeda, Tomohiro

Publication type:

Article

Generating a new Interview Method by using Sensing Technology to Assess Human Emotions.

Published in:

Electronic Journal of Business Research Methods, 2012, v. 10, n. 2, p. 110

By:

Hirose, Yayoi;
Itao, Kiyoshi;
Umeda, Tomohiro

Publication type:

Article

Nasal Rifampicin Improves Cognition in a Mouse Model of Dementia with Lewy Bodies by Reducing α-Synuclein Oligomers.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8453, doi. 10.3390/ijms22168453

By:

Umeda, Tomohiro;
Hatanaka, Yukari;
Sakai, Ayumi;
Tomiyama, Takami

Publication type:

Article

Intranasal rifampicin for Alzheimer's disease prevention.

Published in:

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2018, v. 4, n. 1, p. 304, doi. 10.1016/j.trci.2018.06.012

By:

Umeda, Tomohiro;
Tanaka, Akiko;
Sakai, Ayumi;
Yamamoto, Akira;
Sakane, Toshiyasu;
Tomiyama, Takami

Publication type:

Article

Fabrication of dense β-calcium orthophosphate with submicrometer-sized grains and its high-temperature superplastic deformation.

Published in:

Journal of Materials Science, 2011, v. 46, n. 6, p. 1956, doi. 10.1007/s10853-010-5031-1

By:

Watanabe, Daisuke;
Nishio, Keishi;
Sakka, Yoshio;
Ohgaki, Masataka;
Davies, Ian J.;
Umeda, Tomohiro;
Koda, Seiichiro;
Itatani, Kiyoshi

Publication type:

Article

Experimental study of calcium phosphate cement impregnated with dideoxy-kanamycin B.

Published in:

Journal of Orthopaedic Science, 2007, v. 12, n. 3, p. 281, doi. 10.1007/s00776-007-1124-3

By:

Osamu Kisanuki;
Hiroshi Yajima;
Tomohiro Umeda;
Yoshinori Takakura

Publication type:

Article

A Mouse Model of Amyloid β Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 14, p. 4845, doi. 10.1523/JNEUROSCI.5825-09.2010

By:

Tomiyama, Takami;
Matsuyama, Shogo;
Iso, Hiroyuki;
Umeda, Tomohiro;
Takuma, Hiroshi;
Ohnishi, Kiyouhisa;
Ishibashi, Kenichi;
Teraoka, Rie;
Sakama, Naomi;
Yamashita, Takenari;
Nishitsuji, Kazuchika;
Ito, Kazuhiro;
Shimada, Hiroyuki;
Lambert, Mary P.;
Klein, William L.;
Mori1, Hiroshi

Publication type:

Article