We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
血清生长激素释放肽和肝脏表达抗菌肽-2 与儿童特发性矮身材的相关性.
- Authors
刘青; 张伟淳; 陈波; 宋亚文
- Abstract
Objective To investigate the expression levels of ghrelin and liver-expressed antimicrobial peptide-2 (LEAP-2) in children with idiopathic short stature (ISS) to provide reference for further understanding the etiology of short stature. Methods A prospective study was conducted from December 2021 to October 2023, involving 46 children diagnosed with ISS (ISS group) and 46 healthy children with normal height (control group) at the First Affiliated Hospital of Shihezi University. General data and serum levels of ghrelin and LEAP-2 were compared between the two groups. The predictive value of these two indicators for ISS was evaluated using receiver operating characteristic (ROC) curve analysis. Results The serum level of ghrelin in the ISS group was higher than that in the control group, while the level of LEAP-2 was lower (P0.8. The optimal cutoff values for ghrelin, LEAP-2, and the LEAP-2/ghrelin ratio were 5 607 pg/mL, 1 155 pg/mL, and 0.212, respectively. In children with ISS, ghrelin showed a negative correlation with chronological age, LEAP-2, and the LEAP-2/ghrelin ratio (P<0.05), while it was positively correlated with growth rate and peak growth hormone levels (P<0.05). LEAP-2 was negatively correlated with growth rate, peak growth hormone levels, and ghrelin (P<0.05), but positively correlated with chronological age and the LEAP-2/ghrelin ratio (P<0.05). Conclusions Ghrelin and LEAP-2 are correlated with the occurrence of ISS, which may provide references for the diagnosis and etiological analysis of children with ISS.
- Subjects
GHRELIN receptors; RECEIVER operating characteristic curves; SHORT stature; LOGISTIC regression analysis; AGE
- Publication
Chinese Journal of Contemporary Pediatrics, 2024, Vol 26, Issue 12, p1261
- ISSN
1008-8830
- Publication type
Academic Journal
- DOI
10.7499/j.issn.1008-8830.2404038