遗传性癫癎与药物精准治疗的研究进展.

吕格; 综述; 韩蕴丽; 审校

Epilepsy is a common nervous system disease. It has been found that the pathogenesis of epilepsy is associated mutations in various genes, including genes encoding voltage-dependent ion channel, genes encoding ligand-gated ion channel, and solute carrier family genes. Different types of epilepsy caused by different mutations have different responses to drugs, and therefore, diagnosis and medication guidance based on genes are new thoughts for developing therapies. With the application of next-generation sequencing technology, more and more genes will be determined, which helps to further study the pathogenic mechanism of mutant genes and provides a basis for precision drug therapy for epilepsy.

NEUROLOGICAL disorders; LIGAND-gated ion channels; ION channels; GENE families; DRUG therapy

Chinese Journal of Contemporary Pediatrics, 2017, Vol 19, Issue 10, p1118

1008-8830

Academic Journal

10.7499/j.issn.1008-8830.2017.10.017