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- Title
THIOL/DISULPHIDE HOMEOSTASIS AND VASCULAR ENDOTHELIAL GROWTH FACTOR LEVELS IN SALIVA OF TYPE 1 DIABETIC CHILDREN WITH GINGIVITIS.
- Authors
KELEŞ, Sultan; ÇEVİK, Özge; ANIK, Ahmet; ANIK, Ayşe; ABAS, Burçin İrem
- Abstract
Objective: To evaluate the thiol/disulphide homeostasis and level of vascular endothelial growth factor (VEGF) in saliva of patients with type 1 diabetes mellitus and gingivitis. Materials and Methods: Forty children with type 1 diabetes mellitus (DM) and 40 systemically healthy (H) children were included the study. Based on children’ periodontal and systemic health status, they were divided into four subgroups: 1) systemically and periodontally healthy subjects (Hh), 2) systemically healthy subjects with gingivitis (Hg), 3) diabetic subjects with periodontal health (DMh), 4) diabetic subjects with gingivitis (DMg). Probing depth (PD), gingival index (PI) and plaque index (PI) were recorded. An automated technique was used to measure the thiol/disulphide homeostasis parameters, and ELISA was used to measure the VEGF concentrations in unstimulated whole saliva. Results: DM and H groups had comparable clinical periodontal parameters and salivary VEGF levels (p>0.05). GI, PI, PD, and disulphide amounts were significantly higher in the gingivitis subgroups (Hg and DMg) than in the periodontally healthy subgroups (Hh and DMh) (p<0.001). The gingivitis subgroups (Hg and DMg) had significantly higher amounts of VEGF compared to the periodontally healthy subgroups (Hh and DMh) (p<0.001). Conclusions: Thiol/disulphide homeostasis shifts towards disulphide direction in diabetic children with gingivitis. Thiol/disulphide homeostasis and VEGF levels in saliva may be diagnostic markers of gingival inflammation.
- Subjects
DIABETES in children; VASCULAR endothelial growth factors; GINGIVITIS; OXIDATIVE stress; SALIVA; DIABETES
- Publication
Meandros Medical & Dental Journal, 2024, Vol 25, Issue 4, p451
- ISSN
2149-9063
- Publication type
Academic Journal
- DOI
10.69601/meandrosmdj.1596241