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- Title
Dietary fiber intake is associated with chronic kidney disease (CKD) progression and cardiovascular risk, but not protein nutritional status, in adults with CKD.
- Authors
Lu Lu; Yan-Feng Huang; Ming-Qing Wang; De-Xiu Chen; Heng Wan; Lian-Bo Wei; Wei Xiao; Lu, Lu; Huang, Yan-Feng; Wang, Ming-Qing; Chen, De-Xiu; Wan, Heng; Wei, Lian-Bo; Xiao, Wei
- Abstract
Background and Objectives: Evidence suggests that dietary fiber benefits patients with chronic kidney disease (CKD); however, this conclusion requires further validation. In this study, we examined the effects of dietary fiber on kidney function, inflammation, indoxyl sulfate, nutritional status, and cardiovascular risk in patients with advanced CKD.Methods and Study Design: We performed linear regressions to assess the association between dietary fiber intake and CKD parameters. The aforementioned parameters were compared over an 18-month follow- up period. Kaplan-Meier analysis was used to investigate the association between fiber intake and Cardiac vascular disease (CVD).Results: In total, 157 patients were included in this study. Dietary fiber and inflammatory indices were associated (interleukin [IL]-6: β=-0.024, p=0.035). The differential estimated glomerular filtration rate (ΔeGFR) as well as levels of C-reactive protein, IL-6, indoxyl sulfate, and serum cholesterol in the higher fiber intake (>=25 g/day) group were lower than those in the lower fiber intake (0.05).Conclusions: Our results suggest that increasing fiber intake can retard the decrease in the eGFR; can reduce the levels of proinflammatory factors, indoxyl sulfate, and serum cholesterol; and is negatively associated with cardiovascular risk, but does not disrupt the nutritional status of patients with CKD.
- Subjects
KIDNEY disease risk factors; REGRESSION analysis; CARDIOVASCULAR diseases risk factors; NUTRITIONAL status; DIETARY fiber; CARDIOVASCULAR diseases; CHRONIC kidney failure; LONGITUDINAL method; DIETARY proteins
- Publication
Asia Pacific Journal of Clinical Nutrition, 2017, Vol 26, Issue 4, p598
- ISSN
0964-7058
- Publication type
Academic Journal
- DOI
10.6133/apjcn.072016.08