Benefit of oral nutritional supplements for children with acute lymphoblastic leukaemia during remission-induction chemotherapy: a quasi-experimental study.

Rui Liang; Gai-Yun Chen; San-Xian Fu; Jie Zhong; Yan Ma; Liang, Rui; Chen, Gai-Yun; Fu, San-Xian; Zhong, Jie; Ma, Yan

Background and Objectives: To determine the effect of oral nutritional supplements (ONS) on children with acute lymphoblastic leukaemia undergoing remission-induction chemotherapy.Methods and Study Design: We included 127 paediatric patients who were diagnosed with acute lymphoblastic leukaemia and undergoing remission- induction chemotherapy in the First Affiliated Hospital of Zhengzhou University. Children from two paediatric wards who met the inclusion criteria were enrolled. One ward was randomly chosen as the intervention group and the other ward as the control group. Children in the two groups were matched for age and sex. The ONS group was administered Peptamen® (n=60) and the control group was administered a low-fat diet (n=67).Results: The baseline information before treatment was not significantly different between groups (p>0.05). In the control group, weight loss at the end of chemotherapy was significantly higher than that of ONS group (pConclusions: During remission-induction chemotherapy, oral nutritional supplements can improve the nutritional status of children, reduce the incidence of complications, and decrease the costs of hospitalization.

CHINA; DIETARY supplements; LYMPHOBLASTIC leukemia; LYMPHOBLASTIC leukemia treatment; CANCER chemotherapy; WEIGHT loss; PATIENTS; THERAPEUTICS; RESEARCH methodology; DISEASE incidence; LOW-fat diet; UNIVERSITIES & colleges; DISEASE remission; ELEMENTAL diet; CHILDREN

Asia Pacific Journal of Clinical Nutrition, 2018, Vol 27, Issue 1, p144

0964-7058

Academic Journal

10.6133/apjcn.032017.04