Vascular Senescence and Resistance Exercise Training: Focus on Circulating Endothelial Cell- Derived MicroRNA-92a and Endothelin-1.

Hashemi, Ayoub; Soori, Rahman; Banitalebi, Ebrahim; Choobineh, Siroos

Background and objectives: Vascular senescence refers to specific agingassociated changes in the endothelial cells. The purpose of this study was to investigate effects of 12 weeks of resistance training with elastic bands on circulating endothelial cellderived microRNA-92a and endothelin-1 (ET-1) in elderly women with osteosarcopenic obesity (OSO). Methods: In the present randomized clinical trial, 48 elderly women with OSO were randomly divided into a control group (n=22) and an experimental group (n=26). The subjects in the intervention group performed 12 weeks of resistance training with elastic bands three times a week. The participants became familiar with targeted number of repetitions and OMNI-resistance exercise scale to control exercise intensity. Results: The mean age, body fat percentage, body mass index (BMI), and bone mineral density T-score for the hip and L1-L4 lumbar spine of the subjects were 64.13±3.68 years, 45.4%±6.56, 33.1±3.71 kg/m², and -1.86±1.42, respectively. After the 12-week resistance training, we observed a significant decrease in serum level of mir-92a in the experimental group compared to the control group (p=0.03). However, there was no significant difference between the study groups in terms of body weight, BMI, body fat percentage, total cholesterol, and ET-1 (p≥0.05). Conclusion: The 12-week resistance training program seems to modulate and decrease serum mir-92a expression in elderly women with OSO. The lack of a significant change in BMI, body fat percentage, and ET-1 levels following the exercise training might be due to the type and intensity of the exercises.

RESISTANCE training; EXERCISE therapy; VASCULAR resistance; PREPROENDOTHELIN; OLDER women; BONE density; TERIPARATIDE; FAT

Medical Laboratory Journal, 2022, Vol 16, Issue 2, p34

2538-4449

Academic Journal

10.61186/mlj.16.2.34