Metabolic effects of polycystic ovary syndrome in adolescents.

Yejin Han; Hae Soon Kim; Hye-Jin Lee; Jee-Young Oh; Yeon-Ah Sung

Purpose: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenic anovulation in women of reproductive age. We investigated the metabolic effects of lean and overweight adolescents with PCOS. Methods: Anthropometric measurements and biochemical parameters were evaluated in 49 adolescents with PCOS and 40 age- and body mass index (BMI)- matched controls. We further divided both PCOS and control groups into those having BMI within the normal range of less than 85th percentile and those being overweight and obese with a BMI greater than 85th percentile. Results: Hemoglobin, gamma-glutamyl transferase (r-GT), total cholesterol, lowdensity lipoprotein-cholesterol and 2-hour postglucose load plasma insulin levels were significantly elevated in the lean PCOS group than in the lean control group. In the overweight/obese PCOS group, hemoglobin and r-GT levels were significantly elevated than in the overweight/obese control group. In the normal weight group, none of the subjects had metabolic syndrome according to the Adult Treatment Panel III criteria, but the incidence of metabolic syndrome in the overweight/obese PCOS group was 8.3% and that in the overweight/obese control group was 6.7%. Conclusion: PCOS in adolescents causes metabolic abnormalities, underscoring the importance of early diagnosis of PCOS in oligomenorrheic adolescents.

POLYCYSTIC ovary syndrome; METABOLIC syndrome; TEENAGE girls; DISEASES

Annals of Pediatric Endocrinology & Metabolism, 2015, Vol 20, Issue 3, p136

2287-1012

Academic Journal

10.6065/apem.2015.20.3.136