Background: self-polymerizing acrylic resins are the common materials used for the construction of orthodontic appliances. These materials have to be deficient some mechanical properties. The aim of the present research was to assess the impact of adding zinc oxide fillerstoself-polymerizing acrylic resins on their tensile strength. Materials and method: thirty samples were fabricated in total. They were made from self-polymerizing acrylic resin. 20 specimens were strengthened with zinc oxide powder at 1% and 2% by weight respectively, and the other ten specimens were considered as control. The tensile test was conducted for each specimen. The data were analyzed using SPSS v 20, and comparison between main groups was obtained by ANOVA and Duncan's test. Results: The results showed that the ZnO enhanced significantly the tensile strength of self-polymerizing acrylic resin compared to the control group. The ZnO 1 experimental group has the highest mean of tensile strength (6.97 N/mm2) followed by ZnO 2(5.91 N/mm2). Conclusion: the incorporating of ZnO powder to self-polymerizing acrylic resins affects significantly the tensile strength. It is suggested to add ZnO fillers with different concentrations to see whether there is any improvement in the mechanical properties of self-polymerizing acrylic resins or not.