The goal of the present work is to achieve the nuclear data for medically important radioisotope Iodine-125. The Measured data of excitation functions for direct reactionsof particle induced nuclear reactions, which produced 125I, are available in EXFOR library have been evaluated and recommended in this work. This evaluation is used to calculate the integral yield of radioactive Iodine-125. The average values was derived and used to calculate the most useful reaction for the production of Iodine-125 which is 124Te(d, n)125 I reaction with no impurity, yield 0.611MBq (0.02mCi)/µAh, and useful energy range 5.5→7.5MeV from cyclotron using high enrichment for 124Te.