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- Title
The Role of Overexpression of Rab1A in Human Pancreatic Cancer and its Association with Poor Prognosis.
- Authors
Zwyea, Susan
- Abstract
Rab1 is a member of RAS oncogene family, its role ismediating vesicle transport between the endoplasmic reticulum (ER) and Golgi. Rab1A contributed to human prostate cancer, colorectal cancer (CRC), hepatocellular carcinoma (HCC), gliomasand tongue squamous carcinomas (TSCCs) tumor proliferation and migration. Because pancreatic carcinoma is one of the common human cancers with high lethal malignancy rate, we investigated the expression of Rab1A inpancreatic carcinoma.171 samples with normal pancreatic tissues and 176 samples of pancreatic cancer tissues were obtained and prepared atthe Pathology Clinic, Uppsala University Hospital (Uppsala, Sweden). This study was noticedthat Rab1A is overexpressed in pancreatic carcinoma tissues both in mRNA and protein levels. Moreover, survival analysis showed that Rab1Aoverexpression in human pancreatic carcinoma is associated withpoor prognosis (p<0.05). Strikingly, aberrantexpression of Rab1A in pancreatic carcinoma patients is associated with an elevated level of mTORC1 (p-S6K1) signaling. Our results demonstrate that Rab1A may have apotential role in pancreatic cancer progression in anmTORC1 dependent manner, and further emphasizes the role of Rab1A in human malignancies. Together, these results indicate that Rab1A overexpression couldpromote a new prognostic predictor for human pancreatic cancer. Thus, studying the regulation of Rab1A in pancreatic cancer is urgently needed.
- Subjects
UPPSALA University; PANCREATIC cancer; CANCER associations; PROSTATE cancer; ENDOPLASMIC reticulum; COLON cancer
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 11, p4860
- ISSN
0976-0245
- Publication type
Academic Journal
- DOI
10.5958/0976-5506.2019.03919.6