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- Title
Evaluation of Transaminases, Total Bilirubin and Ferritin in Iraqi Thalassemia Patients.
- Authors
Rasool, Khetam Habeeb; Hussein, Nadheema Hammood; Taha, Butheina M.
- Abstract
Background: Thalassemia is a hereditary disease which characterize by a severe form of anemia occurring early in life associated with splenomegaly and bones changes. Aim: The aim of this study was to evaluate the serum levels of ALT (Alanine transaminase), AST (Aspartate transaminase), bilirubin and ferritin in Iraqi β-thalassemia patients. Subjects and Method: Fifty Iraqi patients diagnosed clinically by hematology doctors as β-thalassemia major (TM) were enteredin this study, they conducted to Ibn AL-Baladi hospital/Baghdad during the period from December, 2017 to march, 2018.The age ranges of patients were (6-36) years, twenty healthy age match were used as control group (Cot). Blood samples (3-5) ml, were collected from the two groups under study TM and control group. Serum was separated, drawn in two plane test tubes, and kept frozen (-20 °c) till the use. Ferritin levels were measured by using Ferritin (Kit Ref 04491785 of cobas e 411 analyzer) according to the manufacturing company. Total Serum Bilirubin concentration (TSB), Transaminases (GOT&GPT) activity were also measured by colorimetric methods, according to ELITech kit, Ref. BITO-0250 France for Bilirubin, and according to ELITech kit, Ref.ALSL-0455 France, for Transaminases/ France, using flexor 150 apparatus. Findings: Results indicated that serum GOT and GPT were significantly elevated in TM patients (47.560 ± 30.472) U/L and (58.755 ± 5.369) U/L respectively in comparisons to their levels in the control group (19.940 ±9 .427) U/L and (8.231 ± 3.830) U/L respectively, also a significant increase in serum Ferritin concentration (2668.±1775.436) ng/dl in TM patients in comparison with control group (31.000±4.735) ng/dl, with an elevated levels in mean value of serum TSB in thalassemia patients (34.76 2 ± 18.526) in comparison to control group (8.231 ± 3.830). Conclusion: Increase ALT (Alanine transaminase), AST (Aspartate transaminase), bilirubin and ferritin inthalassemiapatients may refer to liver dysfunction.
- Subjects
FRANCE; BAGHDAD (Iraq); FERRITIN; AMINOTRANSFERASES; ALANINE aminotransferase; BILIRUBIN; THALASSEMIA
- Publication
Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 11, p4840
- ISSN
0976-0245
- Publication type
Academic Journal
- DOI
10.5958/0976-5506.2019.03916.0