Possible Role of BK Polyomavirus in Prostate Cancer.

Al-Bayati, Asmaa M. S.; Sulaiman, Zaid Mohammed; Sulaiman, Maad Mohammed; Alazzawy, Muhannad Abdullah

The study was conducted in Kirkuk city-Iraq from of February 2018 to September 2018. The number of prostate cancer patients under study were 60 patients whose ages were between 40-70 years old. These patients admitted to Kirkuk oncology center. The control group who were matched to the patients studied, included 30 healthy blood donor and their ages were between 30-75 years old. Blood samples were collected for detection of BK polyomavirus DNA by real time-PCR. The study showed that the highest rate of BK polyomavirus DNA occurrence were recorded in patients with prostate cancer when compared with control group (51.66% versus 3.33%) (P: <0.01). The study showed that the highest mean level of PSA was recorded in patients with prostate cancer comparing with the control group (78.42 v.s. 3.40 ng/ml). The result was highly significant. The present study demonstrated that the highest mean level of PSA was found in prostates cancer patients who were positive to BK polyomavirus DNA comparing with BK polyomavirus DNA negative (52.54 versus 25.88 ng/ml). It was concluded that BK polyomavirus was frequently detected in prostate cancer patients and could play a relevant role in the development and progression of human prostate cancer.

KIRKUK (Iraq); IRAQ; POLYOMAVIRUSES; PROSTATE cancer; PROSTATE cancer patients

Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 10, p1628

0976-0245

Academic Journal

10.5958/0976-5506.2019.03074.2