A Comparison Between Luteal Phase Treatment with Estradiol and GnRH Antagonist for Ovarian Follicular Synchronization in ICSI Cycle.

Aubead, Nassrin Malik; Ghazali, Basima Sh. AL.; Abbood, Muayad Sraibet

The Objective of this study is to compare the results of luteal phase treatment by estradiol versus GnRH antagonist on antral follicular size coordination and hormonal levels before ICSI cycles, assessment of follicular growth synchronization during controlled ovarian stimulation and evaluate ICSI outcome. This a prospective randomized clinical trial included 60 infertile women evaluated in second day of menstrual cycle for antral count and their sizes, FSH,LH, estradiol, and progesterone, then assigned randomly according to luteal treatment to 3 groups; with 20 patients in each treated with estradiol,or cetrorelix acetate or no treatment. All then enrolled in ICSI with flexible antagonist protocol. Findings revealed significantly reduction of antral follicles sizes, and improve their growth symmetry in early follicular phase after treatment, reduction in second day FSH,LH and progesterone. Reduction in follicular growth discrepancies at day 8. At trigger day the antagonist group had a significant more numbers of the follicles size ≥17 mm. larger number of retrieved–oocytes, (MII) than other groups, (P<0.05). No significant difference in biochemical and clinical pregnancy rates between groups. In conclusions premenstrual estradiol or GnRH antagonist treatment decrease size discrepancies of antral follicles, and improve synchronization of their growth.

LUTEAL phase; ESTRADIOL; INDUCED ovulation; OVARIAN function tests; SYNCHRONIZATION; MENSTRUAL cycle

Indian Journal of Public Health Research & Development, 2019, Vol 10, Issue 8, p1229

0976-0245

Academic Journal

10.5958/0976-5506.2019.02063.1