Results
Title

Potential Honey Propolis Trigona to Prevent Arthritis Rheumatoid by Increase Foxp3 Level; A Preliminary Study.

Authors

Abdullah, Andi Zulkifli; Bukhari, Agussalim; Aliyah; Usman, Andi Nilawati

Abstract

Background: Rheumatoid arthritis is an autoimmune disease and need the balancing of immune system. Foxp3 Treg level is one of critical regulator to balance system immune. This study aim to analyze potential of propolis and honey propolis for prevention rheumatoid arthritis based on Foxp3 Treg as a target. Methods: It was a quasi-experimental study with pretest-posttest control design, Subject divided into 3 groups, group 1 control did not give anything, group2 given propolis 60 mg/capsule and group 3 given honey propolis 35 mg/pack. Propolis and Honey Propolis Trigona was giving through 14 days and blood sample for ELISA examination taken three times, Before intervention (baseline), 7 day after intervention and 14 days after intervention. Results: Analysis mean difference between baseline data with 14 days data show giving honey propolis has the highest increase of Foxp3 Treg and giving propolis has the lowest increase of Foxp3 Treg. Among the three groups, only the group given honey propolis has a significant effect. Conclusion: Honey propolis has potential effect as therapy for prevention arthritis rheumatoid by increase Foxp3 Treg level. Adherence to consume honey propolis is necessary to provide the maximum effect.

Subjects

RHEUMATOID arthritis; PROPOLIS; HONEY; AUTOIMMUNE diseases; IMMUNE system

Publication

Indian Journal of Public Health Research & Development, 2018, Vol 9, Issue 12, p1353

ISSN

0976-0245

Publication type

Academic Journal

DOI

10.5958/0976-5506.2018.02041.7