Results
Title

Oxidative stress of crystalline lens in rat menopausal model.

Authors

ACER, SEMRA; PEKEL, GÖKHAN; KÜÇÜKATAY, VURAL; KARABULUT, AYSUN; YAĞCI, RAMAZAN; ÇETIN, EBRU NEVIN; AKYER, şAHIKA PINAR; şAHIN, BARBAROS

Abstract

Purpose: To evaluate lenticular oxidative stress in rat menopausal models. Methods: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Group 1). From the rats that underwent oophorectomy, 10 formed the menopause control group (Group 2), 10 were administered a daily injection of methylprednisolone until the end of the study (Group 3), and the remaining 10 rats were administered intraperitoneal streptozocin to induce diabetes mellitus (Group 4). Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurements of the crystalline lenses were analyzed. Results: The mean OSI was the lowest in group 1 and highest in group 4. Nevertheless, the difference between the groups was not statistically significant in terms of OSI (p>0.05). The mean TOS values were similar between the groups (p>0.05), whereas the mean TAC of group 1 was significantly higher than that of the other groups (p<0.001). Conclusions: Our results indicate that menopause may not promote cataract formatio.

Subjects

OXIDATIVE stress; CRYSTALLINE lens; LABORATORY rats; MENOPAUSE; TREATMENT of cataracts; OVARIECTOMY; METHYLPREDNISOLONE; STREPTOZOTOCIN; THERAPEUTICS

Publication

Arquivos Brasileiros de Oftalmologia, 2016, Vol 79, Issue 4, p222

ISSN

0004-2749

Publication type

Academic Journal

DOI

10.5935/0004-2749.20160064