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Title

Compromised T-cell immunity in patients with spinal cord injury and its relationship with injury characteristics.

Authors

Kartal, Ozgur; Yilmaz, Bilge; Gülec, Mustafa; Guzelkucuk, Umüt; Tan, Arif Kenan; Sener, Osman; Muşabak, Uğur

Abstract

Objectives: The aim of this study was to investigate in vivo and in vitro cellular immune responses in patients with chronic (spinal cord injury; SCI), determine the effects of autonomic dysfunction on cellular immune response, and determine the effect of completeness of the injury at different levels on cellular immune response. Patients and methods: Forty-nine patients (42 males, 7 females; mean age: 35.5±13.4 years; range, 18 to 68 years) with chronic (time since injury >6 months) traumatic SCI were included in this cross sectional study between March 2013 and December 2013. Patients were allocated into two groups: Group 1, patients with an injury at T7 or below, and Group 2, patients with an injury at T6 or above. All patients in Group 2 had a history of autonomic dysreflexia and orthostatic hypotension. Intradermal skin tests were applied to the participants to reveal delayed T-cell responses. The percentages of cluster of differentiation (CD)3 T cells and CD3 T cells expressing CD69 and CD25 were analyzed by flow cytometry for the detection of activated T cells including all T-cell subsets. Results: When patients with complete injuries were compared, the CD45 cell percentage was found to be significantly higher in patients in Group 2. Patients with an incomplete SCI had increased skin response to candida antigens compared to complete SCI patients. Incomplete SCI patients also had higher percentages of lymphocytes and CD3 CD25 and CD3 CD69 T cells compared to patients with complete SCI. Conclusion: T-cell activity is impaired in chronic SCI patients with higher levels of injury, and the completeness of injury and autonomic dysfunction gain prominence as compromising factors in T-cell immunity.

Subjects

TURKEY; BIOMARKERS; IN vitro studies; FLOW cytometry; DELAYED hypersensitivity; STATISTICS; SPINAL cord injuries; IN vivo studies; SKIN tests; ACADEMIC medical centers; AUTONOMIC nervous system diseases; CHRONIC diseases; ORTHOSTATIC hypotension; MANN Whitney U Test; FISHER exact test; T-test (Statistics); PEARSON correlation (Statistics); COMPARATIVE studies; SYMPTOMS; DESCRIPTIVE statistics; CHI-squared test; T cells; CELLULAR immunity; AUTONOMIC dysreflexia; STATISTICAL sampling; DATA analysis software; DATA analysis

Publication

Turkish Journal of Physical Medicine & Rehabilitation (2587-1250), 2023, Vol 69, Issue 1, p69

ISSN

2587-1250

Publication type

Academic Journal

DOI

10.5606/tftrd.2023.11658

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