Orthostatic hypotension and age-related sarcope.

Keskin, Kudret; Çiftçi, Selda; Öncü, Jülide; Doğan, Güneş Melike; Çetinkal, Gökhan; Yıldız, Süleyman Sezai; Sığırcı, Serhat; Kılıçkesmez, Kadriye Orta

Objectives: This study aims to determine the association of sarcopenia with orthostatic hypotension (OH) which is a significant precursor to falls and related injuries in elderly patients. Patients and methods: A total of 91 outpatients (18 males, 73 females; mean age 79.3±4.0 years; range, 75 to 91 years) were prospectively enrolled and those who were eligible underwent comprehensive sarcopenia assessment including measurement of muscle mass, strength, physical performance, anthropometric measurements along with frailty tests. Patients classified as sarcopenic or non-sarcopenic based on these measurements underwent supine and standing blood pressure (BP) measurements. The frequency of OH was compared between the two groups. Results: Of the 91 patients, 29 (31.9%) had sarcopenia. There was no statistical difference in measurements of functional tests which consisted of gait speed, timed up-and-go test and handgrip strength. However, timed sit-to-stand test values were higher in sarcopenic patients (18.2±7.9 vs. 15.0±5.1, p=0.04). Patients with sarcopenia developed OA and intolerance more often compared to the non-sarcopenic patients (n=15 [50.0%] vs. n=14 [23.0%], p<0.01 and n=13 [44.8%] vs. n=9 [15.3%], p<0.01, respectively). The adjusted odds ratio for sarcopenia was 7.80 (95% confidence interval 1.77-34.45), p=0.007. Conclusion: Age-related sarcopenia increases the risk of OA in the elderly. This may in part explain the increased incidence of falls and also help identification of risky elderly patients for orthostatic BP drops.

TURKEY; INJURY risk factors; WALKING speed; GRIP strength; BODY composition; EXERCISE tests; NONPARAMETRIC statistics; STATISTICS; FRAIL elderly; CONFIDENCE intervals; SCIENTIFIC observation; MUSCLE contraction; HEMOGLOBINS; AGE distribution; ANTHROPOMETRY; MULTIPLE regression analysis; MULTIVARIATE analysis; SARCOPENIA; ORTHOSTATIC hypotension; GERIATRIC assessment; MANN Whitney U Test; FISHER exact test; PSYCHOLOGICAL tests; SERUM albumin; COMPARATIVE studies; ACCIDENTAL falls; DESCRIPTIVE statistics; MUSCLE strength; BODY movement; BIOELECTRIC impedance; SPHYGMOMANOMETERS; CHI-squared test; ODDS ratio; LOGISTIC regression analysis; DATA analysis software; BODY mass index; LONGITUDINAL method; DISEASE risk factors; OLD age

Turkish Journal of Physical Medicine & Rehabilitation (2587-1250), 2021, Vol 67, Issue 1, p25

2587-1250

Academic Journal

10.5606/tftrd.2021.5461