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Title

Meldonium jako nowa opcja terapeutyczna w przewlekłej niewydolności i chorobie niedokrwiennej serca.

Authors

Woroń, Jarosław

Abstract

Meldonium has cardioprotective effects in that it regulates the content of carnitine which, in ischemic conditions, switches the energy metabolism from the oxidation of fatty acids to the more energetically favorable oxidation of glucose. The drug also reduces L-carnitine levels through transporter and enzyme inhibition. Meldonium can be used as a complementary therapy in patients with heart failure and coronary artery disease, who despite the use of optimal pharmacotherapy in terms of the choice of drugs and their dosing regimen continue to present symptoms such as chest pain, shortness of breath, impaired exercise tolerance, which significantly affects their quality of life.

Subjects

FATTY acid oxidation; EXERCISE tolerance; OXIDATION of glucose; CORONARY artery disease; HEART failure patients

Publication

Heart & Vascular Diseases / Choroby Serca & Naczyn, 2024, Vol 21, Issue 1/2, p1

ISSN

1733-2346

Publication type

Academic Journal

DOI

10.5603/chsin.99648