We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl / phenyl)benzothiazoles.
- Authors
Yilmaz, Serap; Yalcin, Ismail; Kaynak-Onurdag, Fatma; Ozgen, Selda; Yildiz, Ilkay; Aki, Esin
- Abstract
A new series of 2-[4-(4-substitutedbenzamido / phenylacetamido / phenylpropionamido) benzyl / phenyl]benzothiazole derivatives (6a-6w) were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 200 and 6.25 µg/ml. Compounds 6e and 6j exhibited the greatest activity with MIC values of 6.25 µg/ml against Pseudomonas aeruginosa, and Staphylococcus aureus isolate, respectively.
- Subjects
ANTI-infective agents; BENZYL compounds; BENZOTHIAZOLE derivatives; PHENYLACETATES; STAPHYLOCOCCUS aureus; KLEBSIELLA pneumoniae; ANTIFUNGAL agents
- Publication
Croatica Chemica Acta, 2013, Vol 86, Issue 2, p223
- ISSN
0011-1643
- Publication type
Academic Journal
- DOI
10.5562/cca2064