Study on Inflammation and the Nervous system of Ethanol extract of Jatropha Curcas seed.

Alexander, Zambrano-Huailla; Rommel, Zambrano-Huailla; Sergio, Goicochea-Lugo; Ernesto, Zavala-Flores; Jorge, García-Berrocal; Angel, Chau-Saravia; Carlos, Pante-Medina; Alberto, Salazar-Granara

Introduction: Jatropha curcas L. seeds are used in traditional medicine to treat a variety of diseases or conditions. The aim of this study is to evaluate effects on inflammation and the nervous system of ethanol extract of J. curcas seeds. Materials and methods: It was used 64 mice divided in 8 groups; respectively, 4 groups received 400, 600, 800 and 1000 mg/kg of ethanol extract of J. curcas seed; and the rest intake Diclofenac, Diazepam, Caffeine and a control group not received any substance. The effects on inflammation was evaluated by Carrageenan-Induced paw oedema test and by Paw skin temperature. Neurological symptoms of toxicity were evaluated using the Irwin test. For the analysis of quantitative variables were used the following tests: one-way ANOVA, Tukey, Shapiro-Wilk and Pearson correlation; for qualitative variables Chi square was used. Results: According to the paw oedema, it was showed a trend on an inflammatory effect of the seeds of J. curcas; this activity was statistically significant in doses of 1000 mg/kg. Also, the skin temperature measurements outcomes reveal a positive dose response manner. Regard to neurological manifestations, Straub tail was founded in doses of 400 mg/kg. Stereotypies were founded in doses of 400, 600, 800 and 1000 mg/kg throughout the evaluation. Conclusion: J. curcas seeds were showed an inflammatory effect. In addition, effects on the nervous system were founded as stereotypes and Straub tail.

IRRITATION (Pathology); INFLAMMATION; COUNTERIRRITATION; ANTI-inflammatory agents; PATHOLOGY

Pharmacognosy Journal, 2016, Vol 8, Issue 4, p335

0975-3575

Academic Journal

10.5530/pj.2016.4.5